Get to know those little buggers in your (aging) gut

The next time you poop, take a moment to realize that you have become more human by doing so. Sure, you have gotten rid of some smelly ‘uncivilized’ stuff, but at the same time, a large amount of little buggers have vacated your gut. Since these little buggers live in and on our bodies in about a 1:1 ratio with our own cells1, simply by pooping some out, you have tipped the scale to being slightly more ‘human’. Those little buggers are bacteria, and constitute what scientists call the ‘microbiome’. It’s a thing that (some) scientists love to dig in to, sequencing your poop to find out what types of bacteria live there. These bacteria are involved in the breakdown of food and the production of vitamins, so their impact can be vast. There seem to be good guys and bad guys, but how important is it all?

Gut microbiome and the media

And that is the typical cycle that the media goes through regarding the gut microbiome.

So what can we really say about it? Continue reading

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Exclusive interview with Met Formin

We were lucky enough to get an exclusive interview with the world famous Met Formin, anti-aging expert. Peer inside the head that’s changing the world, and who you just might find sitting in your own house one day. Continue reading

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Your age… or so you think

Check the date:

Aging is traditionally measured in terms of months and years. Makes sense, considering that we all are checking our calendars and celebrating birthdays. Personally though, I always preferred the idea of measuring aging with ‘Chapters’, and that I might be somewhere around Chapter 7 now. In any case, measuring with chronological age years makes more sense if we want to compare between each other, but is chronological age the best way to do it? Continue reading

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Evolution and the limits of lifespans

Why does a human live longer than a mouse?

And why does the bowhead whale live longer than a human? And, as recently discovered1, why can the Greenland shark live around 400 years, beating the bowhead whale? The answer, as with most things in biology, is in our genes. Or more precisely, the millions of years of history hidden in our genes: evolution.

What did evolution do? Continue reading

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Why we should develop medicines that target aging itself

The answer is pretty simple, and I’ll try to outline it in just a few steps.

1) If we go to the CDC website (centers for disease control and prevention) and download death counts for the top 15 causes of death, we can plot the resulting %s as a pie chart, and see right away what’s going on in the US. For example, the top three causes of death can be classified as heart diseases, cancers, and cerebrovascular diseases (i.e. strokes).

Top causes of death pie chart

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OLDY

OLDY

You, what will happen to you, and what you can do about what will happen to you.

Here it is! I call this the “Organized Lifespan-terms Diagram of You” (OLDY) network, with subtitle: “you, what will happen to you, and what you can do about what will happen to you”. Though it doesn’t look like much (other than a big hairball), this is a pretty serious network. It was generated by text-mining the titles of over 14,000 review articles from PubMed published in the last five years on aging, and finding the most represented words and their co-occurrences Continue reading

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